up-regulated – Communicable Diseases Research

Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2

Article

Published on 2022-12-012022-11-16
Journal: Biochemical Genetics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

SARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경

Article

Published on 2022-12-012022-09-11
Journal: Protein & Cell
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

[키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis.
[DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article

Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cells

Article

Published on 2022-11-012022-11-15
Journal: Journal of Endocrinological Investigation
[Category] COVID19(2023년), SARS, 진단,

Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4+/CD8+ cells in COVID-19 patients

Article

Published on 2022-09-232022-11-15
Journal: Medicine
[Category] 바이오마커, 치료제,

[키워드] addition analyzed Apoptosis apoptotic apoptotic cell association blood cell C-reactive protein can be used CD4+ cell CD8+ cell Cell cell count cells characterized Chest CT Clinical severity confirmed case correlated correlation COVID-19 COVID-19 case COVID-19 patient COVID-19 patients CRP CTLA-4 cytotoxic T-lymphocyte antigen-4 detect Diagnosis diagnostic Dyspnea eosinophil expressing expression ferritin flow cytometry healthy control healthy volunteer In-patients Increased Infectious disease lymphocyte Lymphocyte count lymphopenia neutrophil Patient patients Platelet proportion reduced severity significant difference significantly therapeutic targets Total up-regulated WBCs while white with COVID-19
[DOI] 10.1097/MD.0000000000030650 PMC 바로가기

Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune system

Article

Published on 2022-09-122022-11-15
Journal: PLoS ONE
[Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort

Article

Published on 2022-09-062022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] African Anti-inflammatory Antiviral change children clinically Cohort condition conditions Control controls COVID-19 cytokine differential expression differentially expressed gene down-regulated gene expression febrile febrile illness Follow-up Gene Expression healthy healthy children healthy controls highlight IL-27 IL27 immune gene immune-related gene Inflammatory inflammatory condition inflammatory conditions inflammatory reaction innate immune pathway innate immune system investigated Kawasaki disease lack longitudinal MIS-C multisystem inflammatory syndrome. Other pathway Patient pyroptosis quantitative PCR resolved SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity South South Africa specimen syndrome systemic lupus erythematosus timepoints Treatment two group unique up-regulated was determined
[DOI] 10.3389/fimmu.2022.992022 PMC 바로가기

In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19

통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈

Article

Published on 2022-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol
[Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics transcriptomics. up-regulated USP18 viral infectious disease
[DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article

Integrated COVID-19 Predictor: Differential expression analysis to reveal potential biomarkers and prediction of coronavirus using RNA-Seq profile data

통합 COVID-19 예측자: RNA-Seq 프로필 데이터를 사용하여 잠재적인 바이오마커 및 코로나바이러스 예측을 밝히기 위한 차등 발현 분석

Article

Published on 2022-08-012022-09-11
Journal: Computers in biology and medicine
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종,

[키워드] Accuracy adjusted Analysis applied association bioinformatics Biomarker classification Classifier collected Consensus Control coronavirus COVID-19 COVID-19 cases COVID-19 pandemic DEGs DESeq2 Differential expression analysis differentially expressed gene Differentially expressed genes disease transmission down-regulated genes experiment experimental analysis expressed feature filtered gene count Genome healthy identify input intersection and union issue Limma machine machine learning machine learning model machine learning models matter moderate P-value pandemic performed Potential biomarker potential biomarkers predict prediction predictor processed RNA-Seq SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2. sequence significantly Spread statistical SVM the SARS-CoV-2 virus trend up-regulated viral disease Virology
[DOI] 10.1016/j.compbiomed.2022.105684 PMC 바로가기 [Article Type] Article

Eosinophilic esophagitis auxiliary diagnosis based on a peptide ligand to eosinophil cationic protein in esophageal mucus of pediatric patients

Research

Published on 2022-07-182022-10-05
Journal: Scientific Reports
[Category] 바이오마커,

Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ω

SARS-CoV-2에 대한 국소 인터페론 반응의 연령별 비교는 IFN-ε 및 -ω에 대한 역할을 제안합니다

Article

Published on 2022-07-122022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료제,

[키워드] activated Adults age anti-SARS-CoV-2 basal Basal transcription characterized children component components contribute develop diagnostic disease effective expression Genes highest Hospitalization IFN IFN response IFN-stimulated genes IFN-α IFN-ε IFN-λ1 IFN-ω IFNs individual infected individuals Infection Innate immunity interferon ISG ISG15 ISGs Mild Mild disease nasopharyngeal cell nasopharyngeal cells non-infected Occurrence Older overexpressed Protective quantified recent recognize relative expression response resulting risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals severe COVID-19 significantly higher starting swabs Symptom Transcription transcriptomic analysis type I type I and III IFNs type I interferon type I interferon. type III up-regulated
[DOI] 10.3389/fimmu.2022.873232 PMC 바로가기 [Article Type] Article